Sialic Acid Products

Sialic acids (neuraminc acid derivatives) are most often found at the terminal position of glycans, and therefore are a likely point of contact for glycan-ligand interactions. Sialic analysis is a regulatory requirement laid out in the ICH Q6B guidelines for the characterization of biopharmaceuticals.

Sialic acid labeling kit HPLC chromatogram and DMB dye diagram

DMB Sialic Acid Labeling Kit

The LudgerTag DMB Sialic Acid Labeling Kit has been developed for the qualitative analysis of sialic acids
The kit contains reagents for the release of sialic acids from glycoproteins. Released sialic acids are conjugated with DMB dye by an amination-cyclisation reaction.

The kit contains reagents and materials for up to 22 samples including the sialic acid reference panel, and the N-acetyl neuraminic acid and N-glycolyl neuraminic acid standards.

View product documentation as PDF
View Certificate of Analysis as PDF

Part Number: LT-KDMB-A1

LudgerSep uR2 2.1x100mm UHPLC column

uR2 2.1x100mm UHPLC Column

The LudgerSep uR2 2.1x100mm column has been developed for UHPLC analysis of sialic acids labeled with DMB using the LudgerTag DMB Sialic Acid Labeling Kit.

Dimensions: 2.1mm x 100mm

View product documentation as PDF
View Certificate of Analysis as PDF

Part Number: LS-UR2-2.1x100

Sialic Acid Quantitation Kit

The SialiQuant Sialic Acid Quantitation Kit contains all the reagents to quickly and accurately quantitate sialic acids, including N-acetylneuraminic acid (NANA), N-glycolylneuraminic acid (NGNA).

View product documentation as PDF

Part Number: KE-SIALIQ

Sialic Acid Aldolase

Converts sialic acid to N-acetylmannosamine & pyruvate. Sialic acids can then be quantitated by a coupled reaction with NADH and lactic dehydrogenase

View product documentation:
Specsheet    CoA   MSDS

Part Number: E-ALD01

CMP-Sialic Acid Synthetase image

CMP-Sialic Acid Synthetase

This enzyme catalyzes the synthesis of CMP sialic acid from CTP & sialic acid.
The resulting molecule can then be covalently attached to an oligosaccharide by sialyltransferase.

View product documentation as PDF

 

Part Number: E-CMP01

Neuraminidase Au image

Neuraminidase Au

recombinant from A. ureafaciens

View product documentation:
Specsheet    CoA    MSDS

Part Number - Amount of Enzyme
E-S001       - 60 µLs¹
E-S001-20   - 20 µLs¹
E-S001-200 - 200 µls²
   ¹ includes buffer
   ² includes enzyme only

$198$1,377
Neuraminidase Cp image

Neuraminidase Cp

Neuraminidase Cp cleaves all non-reducing terminal non-branched α(2-3) and α(2-6) sialic acid residues from complex carbohydrates and glycoproteins.

recombinant from C. perfringens

View product documentation:
Specsheet    CoA    MSDS

Part Number - Amount of Enzyme
E-S005       - 60 µLs¹
E-S005-20   - 20 µLs¹
E-S005-200 - 200 µls²
   ¹ includes buffer
   ² includes enzyme only

$198$1,377
Neuraminidase Sp image

Neuraminidase Sp

Sialidase Sp cleaves the non-reducing terminal α(2-3) unbranched sialic acid residues from complex carbohydrates and glycoproteins.

recombinant from Streptococcus pneumoniae in E. Coli

View product documentation:
Specsheet   CoA    MSDS

Part Number - Amount of Enzyme
E-S007       - 60 µLs¹
E-S007-20   - 20 µLs¹
E-S007-200 - 200 µls²
   ¹ includes buffer
   ² includes enzyme only

$198$1,377
NANA standard

NANA standard – Quantitative

The N-acetylneuraminic acid (NANA) standard is a quantitative standard of NIST-F and USP traceable Neu5Ac monosaccharide.

View product documentation as PDF
Download Non-hazardous MSDS

Part numbers:
    CM-NEU-AC-01   1 nmols
    CM-NEUAC-100  100 nmols

$73$209
NGNA standard (N-glycolylneuraminic acid or Neu5Gc)

NGNA Standard – Quantitative

The N-glycoylneuraminic acid (NGNA) standard is a quantitative standard of NIST-F and USP traceable Neu5Gc monosaccharide.

View product documentation as PDF
Download Non-hazardous MSDS

Part numbers:
    CM-NEU-GC-01   1 nmols
    CM-NEUGC-100  100 nmols

$73$209
Neu5,9Ac2 sialic acid

Neu5,9Ac2

5-N-acetyl-9-O-acetyl neuraminic acid standard (Neu5,9Ac2)

View product documentation as PDF
Download Non-hazardous MSDS

~1 nmol (of which >750 pmol is Neu5,9Ac2)

Part Number: CM-NEU5,9AC2-01

Sialic acid reference panel

Sialic Acid Reference Panel

The Sialic Acid Reference panel is a mixture of different sialic acids forms (as detailed on chromatogram below) sourced from bovine submaxillary mucin.

It includes the following sialic acids: Neu5Ac; Neu5Gc; Neu5,7Ac2; Neu5,Gc9Ac; Neu5,9Ac2; Neu5,7,(8),9Ac3Gc.

Amount: approx. 1.25 nmols

View product documentation as PDF
Download Non-hazardous MSDS

Part Number: CM-SRP-01