O-Linked

O-linked glycans are a common covalent modification of serine and threonine residues of mammalian glycoproteins. The most common type of O-linked glycans found on secreted mammalian glycoproteins and mucins (proteins conjugated to carbohydrate) is from the addition of N-acytylgalactosamine (GalNac) to serine or threonine residues. The Core 1 structure is generated by the addition of galactose b1-3 to this GalNAc. The Core 2 structure is generated by the further addition of N-acetyl-glucosamine b1-6 to the N-acetyl-galactosamine on the Core 1 structure. In total eight different O-linked glycans core structures have been identified and all of these can be further elongated by the addition of a number of monosaccharides including sialic acids. These O-glycans are present in biopharmaceuticals such as erythropoeitin (EPO), Etanercept (Enbrel) and human Factor VIII (FVIII).

Core 1 and Core 2 O-glycans are also present in biopharmaceuticals such as erythropoeitin (EPO), Etanercept (Enbrel), humanFactor VIII(FVIII), Factor IX and insulin glargine.

The Ludger standards have a purity of >90% as assessed by HILIC-HPLC and can be used as internal references or system suitability standards for peak assignment during HPLC or UPLC analysis.

Core 1 – Galactose-ß-(1-3)-GalNAc Glycan
Core 1 2-AB – Galactose-ß-(1-3)-GalNAc, 2-AB labeled
Sialylated Core 1 2-AB – monosialylated core 1 O-glycan, 2-AB labeled
Disialylated Core 1 2-AB – disialylated core 1 O-glycan, 2-AB labeled
Disialylated Core 2 2-AB – disialylated core 2 glycan, 2-AB labeled

Core 1 Glycan

Galactose-ß-(1-3)-GalNAc Glycan

Amount: 20 micrograms
Molecular weight: 383.4 daltons

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Part Number: SA-CORE1

Core 1 2-AB Glycan

Core 1 2-AB labeled glycan
Galactose-ß-(1-3)-GalNAc

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100 picomoles

Part Number: CAB-C1-01

Sialylated Core 1 Glycan 2-AB Labeled

2-AB labelled sialylated core 1 O-glycan, C1S(3)1

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50 picomoles

Part Number: CAB-C1S(3)1-02

Disialylated Core 1 Glycan – 2-AB Labeled

Disialylated core 1 O-glycan, C1S(3,6)2, 2-AB labeled

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100 picomoles

Part Number: CAB-C1S(3,6)2-01

Disialylated Core 2 Glycan – 2-AB Labeled

2-AB labeled disialylated core 2 glycan, C2S(3,3)2

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100 picomoles

Part Number: CAB-C2S(3,3)2-01