APTS Labeled

APTS labeled glycans (9-Aminopyrene-1,4,6-trisulfonic acid) are commonly used as standards for the analysis of glycoproteins by cappilary electrophoresis (CE). The fluorescent APTS molecule confers a strong negative charge to the APTS labeled glycans resulting in rapid separation via capillary electrophoresis.

APTS Label Mass: 523.38981
Fluorescence: excitation = 428 nm, emission = 500 nm.

Molecular formula: C16H8NNa3O9S3
CAS name/number: 1,3,6-Pyrenetrisulfonic acid, 8-amino-, trisodium salt 196504-57-1

A2 APTS Glycan

APTS labeled disialylated biantennary oligosaccharide

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20 picomoles
2664 daltons

Part Number: CAPTS-A2-01

A2F APTS Glycan

APTS labeled core-fucosylated disialo biantennary oligosaccharide

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20 picomoles
2812 daltons

Part Number: CAPTS-A2F-01

A1F APTS Glycan

APTS labeled core-fucosylated monosialo biantennary oligosaccharide
20 picomoles

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20 picomoles
2521 daltons

Part Number: CAPTS-A1F-01

NA2F APTS Glycan / G2F

APTS labeled core-fucosylated, asialo biantennary oligosaccharide

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20 picomoles
2229 daltons

Part Number: CAPTS-NA2F-01

FA2G1 APTS Glycan / G1F

APTS labeled core-fucosylated, asialo, monogalactosylated biantennary oligosaccharide

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20 picomoles
2066 daltons

Part Number: CAPTS-FA2G1-01

A1 APTS Glycan

APTS labeled monosialo biantennary oligosaccharide

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20 picomoles
2375 daltons

Part Number: CAPTS-A1-01

APTS IgG Library

IgG glycoprotein, APTS labeled
10 picomoles

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Part Number: CAPTS-IGG-01

MAN-5 APTS Glycan

APTS labeled oligomannose oligosaccharide with 5 mannosyl residues
20 picomoles

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20 picomoles
1677 daltons

Part Number: CAPTS-MAN5-01

NA2 APTS Glycan (G2)

APTS labeled asialo galactosylated biantennary oligosaccharide
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20 picomoles
2084 daltons

Part Number: CAPTS-NA2-01

NGA2F APTS Glycan / G0F

APTS labeled core-fucosylated, asialo, agalacto biantennary oligosaccharide

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20 picomoles
1905 daltons

Part Number: CAPTS-NGA2F-01

NGA2 APTS Glycan / G0

APTS labeled asialo agalacto biantennary oligosaccharide

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20 picomoles
1759 daltons

Part Number: CAPTS-NGA2-01

References

Beyer B, Schuster M, Jungbauer A, Lingg N. Microheterogeneity of Recombinant Antibodies: Analytics and Functional Impact. Biotechnol J. 2018 Jan;13(1). doi: 10.1002/biot.201700476. Epub 2017 Sep 25. Review.

Sha S, Agarabi C, Brorson K, Lee DY, Yoon S. N-Glycosylation Design and Control of Therapeutic Monoclonal Antibodies. Trends Biotechnol. 2016 Oct;34(10):835-846. doi: 10.1016/j.tibtech.2016.02.013. Epub 2016 Mar 22. Review

Liu L. Antibody glycosylation and its impact on the pharmacokinetics and pharmacodynamics of monoclonal antibodies and Fc-fusion proteins. J Pharm Sci. 2015 Jun;104(6):1866-1884. doi: 10.1002/jps.24444. Epub 2015 Apr 14.

Jefferis R. Recombinant antibody therapeutics: the impact of glycosylation on mechanisms of action. Trends Pharmacol Sci. 2009 Jul;30(7):356-62. doi: 10.1016/j.tips.2009.04.007. Epub 2009 Jun 22. Review.

Jefferis R. Glycosylation of recombinant antibody therapeutics. Biotechnol Prog 21: pp11-16, 2005

Fernandes D. Demonstrating Comparability of Antibody Glycosylation during Biomanufacturing. European Biopharmaceutical Review. Summer 2005. pp 106 -110