Alpha-Gal

Alpha-gal (Gal-alpha(1-3)-Gal) is a disaccharide fragment found on the glycans of some glycoprotein therapeutics produced in mammalian expression systems – particularly those from mouse-derived cell lines. Galα1-3Gal is a non-human epitope that has caused adverse clinical reactions (including IgE-mediated anaphylaxis) in patients. It could also lead to diminished clinical efficacy due to increased serum clearance.

Gal-alpha(1-3)-Gal is a high priority Glycosylation Critical Quality Attribute (GCQA) and developers of biologic drugs should effectively optimise, measure and control the glycosylation of their products to limit Galα1-3Gal levels throughout the product life cycle.

View Ludger Alpha-Gal Poster – WCBP 2016
“Procainamide labelling as part of a flexible glycoprofiling system for monitoring of Gal-α1-3Gal related Glycosylation Critical Quality Attributes (GCQAs) of monoclonal antibody (mAb) therapeutics throughout the product life cycle.”
Radoslaw P Kozak, Louise Royle, Li Phing Liew, Daniel I R Spencer and Daryl L Fernandes

Alpha Gal glycan

Alpha Gal Glycan

Gal-alpha(1-3)-Gal-beta(1-4)-Gal-alpha(1-3)-Gal

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33 µg / 50 nM
666 Daltons

Part Number: SA-AGAL-03

Alpha Gal 2-AB glycan

Alpha Gal 2-AB Glycan

The 2-AB Alpha Gal glycan is a linear trisaccharide: Gal-alpha(1-3)-Gal-beta(1-4)-GlcNAc.

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100 picomoles

Part Number: CAB-ALPHAGAL-01

Alpha Gal 2-AA glycan

Alpha Gal 2-AA Glycan

The 2-AA Alpha Gal glycan is a linear trisaccharide: Gal-alpha(1-3)-Gal-beta(1-4)-GlcNAc.

View product documentation as PDF
Download Non-hazardous MSDS

100 picomoles

Part Number: CAA-ALPHAGAL-01