Alpha-Gal

Alpha-gal (Gal-alpha(1-3)-Gal) is a disaccharide fragment found on the glycans of some glycoprotein therapeutics produced in mammalian expression systems – particularly those from mouse-derived cell lines.

Galα1-3Gal is a non-human epitope that has caused adverse clinical reactions (including IgE-mediated anaphylaxis) in patients. It could also lead to diminished clinical efficacy due to increased serum clearance.Gal-alpha(1-3)-Gal is a high priority

Glycosylation Critical Quality Attribute (GCQA) and developers of biologic drugs should effectively optimise, measure and control the glycosylation of their products to limit Galα1-3Gal levels throughout the product life cycle.

Alpha Gal graphic
US$208

Gal-alpha(1-3)-Gal-beta(1-4)-Gal-alpha(1-3)-Gal

Product Specsheet
View Non-hazardous SDS

33 µg / 50 nM
666 Daltons

Part Number: SA-AGAL-03